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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol

4a-me-5a-cholest-8-en-3-one + H+ + NADPH → 4a-me-5a-cholest-8-en-3b-ol + NADP+

Reactome: R-HSA-9945784
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:46832, RHEA:46833

Inputs

4a-me-5a-cholest-8-en-3-oneCHEBI:87050, C28H46O, endoplasmic reticulum membrane
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

4a-me-5a-cholest-8-en-3b-olCHEBI:87051, C28H48O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity of HSD17B7 [endoplasmic reticulum membrane]EC 1.1.1.270; UniProt P56937

Literature

Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis Mol. Endocrinol., 2003