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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SDS dimers:PXLP convert L-Ser to PYR and NH4+

L-Ser → NH4+ + PYR

Reactome: R-HSA-9929460
Compartment: cytosol
Rhea: RHEA:19170

Inputs

L-SerCHEBI:33384, C3H7NO3, cytosol

Outputs

NH4+CHEBI:28938, H4N, cytosol
PYRCHEBI:15361, C3H3O3, cytosol

Catalysed by

L-serine ammonia-lyase activity of PXLP-SDS dimers [cytosol]EC 4.3.1.17

Literature

Enzymatic and biochemical properties of a novel human serine dehydratase isoform Biochim Biophys Acta, 2006
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies Biochim. Biophys. Acta, 2008