holo-FDPS dimer binds NBPs

holo-FDPS dimer + NBPs → holo-FDPS dimer:NBPs

Reactome

R-HSA-9717841

Compartment

cytosol

Rhea

None recorded

Literature

1. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase Arch. Biochem. Biophys., 2000
2. Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism J. Med. Chem., 2008
3. Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase J. Med. Chem., 2008
4. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates J. Pharmacol. Exp. Ther., 2001
5. Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells Biochem Biophys Res Commun, 2011
6. Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid J Med Chem, 2010