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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP19A1 binds Aromatase inhibitors

CYP19A1 + Aromatase inhibitors → CYP19A1:Aromatase inhibitors

Reactome: R-HSA-9707353
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

CYP19A1R-HSA-193137, endoplasmic reticulum membrane
Aromatase inhibitorsR-ALL-9707314, cytosol

Outputs

CYP19A1:Aromatase inhibitorsR-HSA-9707321, endoplasmic reticulum membrane

Literature

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo Steroids, 1981
Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor J Steroid Biochem Mol Biol, 1990
Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer Clin Cancer Res, 2002
An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane Cancer, 2002
HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines J Drug Target, 2005
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease J Med Chem, 1991