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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SRD5A2 dehydrogenates TEST to DHTEST

TEST + NADPH + H+ → DHTEST + NADP+

Reactome: R-HSA-9705713
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:50822

Inputs

TESTCHEBI:17347, C19H28O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

DHTESTCHEBI:16330, C19H30O2, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A2 [endoplasmic reticulum membrane]EC 1.3.99.5; UniProt P31213

Literature

Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism Nature, 1991
Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2) Mol Pathol, 1997
A critical review of the origin and control of adrenal androgens Baillieres Clin Obstet Gynaecol, 1997