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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HMGCR dimer binds statins

HMGCR dimer + statins → HMGCR dimer:statins

Reactome: R-HSA-9705584
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

HMGCR dimerR-HSA-191277, endoplasmic reticulum membrane
statinsR-ALL-9705575, cytosol

Outputs

HMGCR dimer:statinsR-HSA-9705595, endoplasmic reticulum membrane

Literature

Binding thermodynamics of statins to HMG-CoA reductase Biochemistry, 2005
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia Molecules, 2020
Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase Am Heart J, 2002
Structural mechanism for statin inhibition of HMG-CoA reductase Science, 2001