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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PXLP-K56-SRR dimer isomerises L-Ser to D-Ser

L-Ser → D-Ser

Reactome: R-HSA-9014766
Compartment: cytosol
Rhea: RHEA:10981

Inputs

L-SerCHEBI:33384, C3H7NO3, cytosol

Outputs

D-SerCHEBI:35247, C3H7NO3, cytosol

Catalysed by

serine racemase activity of PXLP-K56-SRR dimer [cytosol]EC 5.1.1.18

Literature

Serine racemase: a key player in apoptosis and necrosis Front Synaptic Neurosci, 2014
Human serine racemase: moleular cloning, genomic organization and functional analysis Gene, 2000
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine Proc. Natl. Acad. Sci. U.S.A., 2002
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity J. Biol. Chem., 2005
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding J. Biol. Chem., 2010
Characterization and localization of a human serine racemase Brain Res. Mol. Brain Res., 2004