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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PXLP-K56-SRR dimer deaminates D-Ser

D-Ser → PYR + NH4+

Reactome: R-HSA-9014741
Compartment: cytosol
Rhea: RHEA:13978

Inputs

D-SerCHEBI:35247, C3H7NO3, cytosol

Outputs

PYRCHEBI:15361, C3H3O3, cytosol
NH4+CHEBI:28938, H4N, cytosol

Catalysed by

D-serine ammonia-lyase activity of PXLP-K56-SRR dimer [cytosol]EC 4.3.1.18

Literature

Serine racemase: a key player in apoptosis and necrosis Front Synaptic Neurosci, 2014
Human serine racemase: moleular cloning, genomic organization and functional analysis Gene, 2000
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine Proc. Natl. Acad. Sci. U.S.A., 2002
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity J. Biol. Chem., 2005
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding J. Biol. Chem., 2010