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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

1,25(OH)2D binds VDR

1,25(OH)2D + VDR → 1,25(OH)2D:VDR

Reactome: R-HSA-8963915
Compartment: nucleoplasm
Rhea: None recorded

Inputs

1,25(OH)2DCHEBI:17823, C27H44O3, nucleoplasm
VDRR-HSA-375512, nucleoplasm

Outputs

1,25(OH)2D:VDRR-HSA-8963916, nucleoplasm

Catalysed by

nuclear steroid receptor activity of VDR [nucleoplasm]

Literature

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction Mol. Pharmacol., 2005
1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts J. Bone Miner. Res., 2005
Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis Oncotarget, 2017
Extraskeletal effects of vitamin D Endocrinol. Metab. Clin. North Am., 2012
Vitamin D and immune function Nutrients, 2013
Vitamin D and immune function: an overview Proc Nutr Soc, 2012