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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane

CHOL → CHOL

Reactome: R-HSA-8951850
Compartment: cytosol · mitochondrial outer membrane · mitochondrial inner membrane
Rhea: RHEA:39747

Inputs

CHOLCHEBI:16113, C27H46O, mitochondrial outer membrane

Outputs

CHOLCHEBI:16113, C27H46O, mitochondrial inner membrane

Catalysed by

cholesterol transfer activity of TSPO:BZRAP1 [mitochondrial outer membrane]

Literature

Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor J. Biol. Chem., 1999
The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia Genomics, 1993
Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis Endocrinology, 1985
The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane J. Biol. Chem., 1986
Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis Mol. Cell. Endocrinol., 2015