Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

phenylalanine + pyruvate => keto-phenylpyruvate + alanine

L-Phe + PYR → L-Ala + kPPV

Reactome: R-HSA-893593
Compartment: cytosol
Rhea: RHEA:13054

Inputs

L-PheCHEBI:58095, C9H11NO2, cytosol
PYRCHEBI:15361, C3H3O3, cytosol

Outputs

L-AlaCHEBI:57972, C3H7NO2, cytosol
kPPVCHEBI:18005, C9H7O3, cytosol

Catalysed by

L-phenylalanine:pyruvate transaminase activity of PXLP-KYAT1 dimer [cytosol]EC 2.6.1.58

Literature

Purification and characterization of kynurenine aminotransferase I from human brain J Neurochem, 1994
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J Med Chem, 2009
Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase FEBS Lett, 1995
Crystal structure of human kynurenine aminotransferase I J Biol Chem, 2004