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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane

25OH-CHOL + PI4P → 25OH-CHOL + PI4P

Reactome: R-HSA-8868402
Compartment: cytosol · endoplasmic reticulum membrane · Golgi membrane
Rhea: None recorded

Inputs

25OH-CHOLCHEBI:42977, C27H46O2, endoplasmic reticulum membrane
PI4PCHEBI:17526, C11H18O16P2R2, Golgi membrane

Outputs

25OH-CHOLCHEBI:42977, C27H46O2, Golgi membrane
PI4PCHEBI:17526, C11H18O16P2R2, endoplasmic reticulum membrane

Catalysed by

sterol transfer activity of OSBP [cytosol]UniProt P22059

Literature

A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP Cell, 2013