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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

OSBPs transport 25OH-CHOL from ER membrane to plasma membrane

25OH-CHOL → 25OH-CHOL

Reactome: R-HSA-8867667
Compartment: cytosol · endoplasmic reticulum membrane · plasma membrane
Rhea: None recorded

Inputs

25OH-CHOLCHEBI:42977, C27H46O2, endoplasmic reticulum membrane

Outputs

25OH-CHOLCHEBI:42977, C27H46O2, plasma membrane

Catalysed by

sterol transfer activity of OSBPs [cytosol]

Literature

Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments Biochem. J., 2002
Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival J. Biol. Chem., 2014
OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites Lipid Insights, 2015
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket Biochem. J., 2007
Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism Prog. Lipid Res., 2013
Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism Biochem. Pharmacol., 2013