Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HSD17B2 oxidises estradiol (EST17b) to estrone (E1)

NADP+ + EST17b → E1 + NADPH + H+

Reactome: R-HSA-8862137
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:24617

Inputs

NADP+CHEBI:58349, C21H25N7O17P3, cytosol
EST17bCHEBI:16469, C18H24O2, cytosol

Outputs

E1CHEBI:17263, C18H22O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B2 [endoplasmic reticulum membrane]EC 1.1.1.62; UniProt P37059

HSD17B2 oxidises estradiol (EST17b) to estrone (E1)

Inputs

Outputs

Catalysed by

Literature