Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACAT2 condenses 2 Ac-CoA to form ACA-CoA

2 Ac-CoA → ACA-CoA + CoA-SH + H2O

Reactome: R-HSA-8848215
Compartment: cytosol
Rhea: RHEA:21037

Inputs

2 Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol

Outputs

ACA-CoACHEBI:57286, C25H36N7O18P3S, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

acetyl-CoA C-acetyltransferase activity of ACAT2 tetramer [cytosol]EC 2.3.1.9

Literature

Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase Biochem. Biophys. Res. Commun., 1994
Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases Pediatr. Res., 1997