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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HSD17B1 hydrogenates E1 to EST17b

E1 + H+ + NADPH → EST17b + NADP+

Reactome: R-HSA-804969
Compartment: cytosol
Rhea: RHEA:24618

Inputs

E1CHEBI:17263, C18H22O2, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

EST17bCHEBI:16469, C18H24O2, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B1 dimer [cytosol]EC 1.1.1.62

Literature

Integrated view on 17beta-hydroxysteroid dehydrogenases Mol Cell Endocrinol., 2009