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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

G6PC hydrolyzes G6P to Glc and Pi (liver)

G6P + H2O → Pi + Glc

Reactome: R-HSA-71825
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: RHEA:44905

Inputs

G6PCHEBI:58225, C6H11O9P, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Outputs

PiCHEBI:43474, HO4P, endoplasmic reticulum lumen
GlcCHEBI:4167, C6H12O6, endoplasmic reticulum lumen

Catalysed by

glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane]EC 3.1.3.9; UniProt P35575

Literature

Genetic basis of glycogen storage disease type 1a: Prevalent mutations at the glucose-6-phosphatase locus Am J Hum Genet, 1995
The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis J. Biol. Chem., 2002
Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a Science, 1993
Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease Hum. Mutat., 2008