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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GSTZ1 isomerizes 4-MAA

4MAA → 4FAA

Reactome: R-HSA-71173
Compartment: cytosol
Rhea: RHEA:14818

Inputs

4MAACHEBI:17105, C8H6O6, cytosol

Outputs

4FAACHEBI:18034, C8H6O6, cytosol

Catalysed by

maleylacetoacetate isomerase activity of GSTZ1 dimer [cytosol]EC 5.2.1.2

Literature

Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Biochemistry, 2001
Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique Biochem J, 2003
Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a) Acta Crystallogr F Struct Biol Commun, 2014