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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HGD dioxygenates homogentisate

HGTA + O2 → 4MAA + H+

Reactome: R-HSA-71164
Compartment: cytosol
Rhea: RHEA:15450

Inputs

HGTACHEBI:16169, C8H7O4, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

4MAACHEBI:17105, C8H6O6, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol]EC 1.13.11.5

Literature

Crystal structure of human homogentisate dioxygenase. Nat Struct Biol, 2000
The molecular basis of alkaptonuria Nat Genet, 1996
Alkaptonuria: Current Perspectives Appl Clin Genet, 2020
Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase Biochem J, 2005