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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TAT deaminates tyrosine

L-Tyr + 2OG → HPP + L-Glu

Reactome: R-HSA-71155
Compartment: cytosol
Rhea: RHEA:15094

Inputs

L-TyrCHEBI:58315, C9H11NO3, cytosol
2OGCHEBI:16810, C5H4O5, cytosol

Outputs

HPPCHEBI:36242, C9H7O4, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol

Catalysed by

L-tyrosine:2-oxoglutarate transaminase activity of TAT dimer [cytosol]EC 2.6.1.5

Literature

Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations Protein Cell, 2010
The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II FEBS J, 2006
The genetic tyrosinemias Am J Med Genet C Semin Med Genet, 2006