Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O

4aOH-BH4 → qDHB + H2O

Reactome: R-HSA-71146
Compartment: cytosol
Rhea: RHEA:11921

Inputs

4aOH-BH4CHEBI:15642, C9H15N5O4, cytosol

Outputs

qDHBCHEBI:43120, C9H13N5O3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

4-alpha-hydroxytetrahydrobiopterin dehydratase activity of PCBD1 tetramer [cytosol]EC 4.2.1.96

4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O

Inputs

Outputs

Catalysed by

Literature