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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+

qDHB + NADH + H+ → BH4 + NAD+

Reactome: R-HSA-71130
Compartment: cytosol
Rhea: RHEA:32253

Inputs

qDHBCHEBI:43120, C9H13N5O3, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Outputs

BH4CHEBI:59560, C9H15N5O3, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Catalysed by

6,7-dihydropteridine reductase activity of QDPR dimer [cytosol]EC 1.5.1.34

Literature

Structure and expression of human dihydropteridine reductase. Proc Natl Acad Sci U S A, 1987
The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue J Biol Chem, 1993