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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)

NADP+ + EST17b → E1 + NADPH + H+

Reactome
R-HSA-6810594
Compartment
cytosol
Rhea
RHEA:24617

Inputs

Outputs

Catalysed by

  • estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B14 tetramer [cytosol]EC 1.1.1.62

Literature

  1. Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity Biochem. J., 2007
  2. 17β-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer PLoS ONE, 2012