DHCR24 reduces ZYMOL to ZYMSTNL
ZYMOL + NADPH + H+ → ZYMSTNL + NADP+
- Reactome
- R-HSA-6807064
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- RHEA:36399, RHEA:36401
Inputs
- ZYMOLCHEBI:18252, C27H44O, endoplasmic reticulum membrane
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- ZYMSTNLCHEBI:16608, C27H46O, endoplasmic reticulum membrane
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Catalysed by
- Delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]EC 1.3.1.72; UniProt Q15392
Literature
- Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol J. Biol. Chem., 1960
- Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Elife, 2015
- Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis Am J Hum Genet, 2001