DHCR7 reduces 7-dehydroCHOL to CHOL
7-dehydroCHOL + NADPH + H+ → CHOL + NADP+
- Reactome
- R-HSA-6807055
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- RHEA:23984, RHEA:23986
Inputs
- 7-dehydroCHOLCHEBI:17759, C27H44O, endoplasmic reticulum membrane
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- CHOLCHEBI:16113, C27H46O, endoplasmic reticulum membrane
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Catalysed by
- 7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane]EC 1.3.1.21; UniProt Q9UBM7
Literature
- Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol J. Biol. Chem., 1960
- Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Elife, 2015
- Molecular cloning and expression of the human delta7-sterol reductase Proc Natl Acad Sci U S A, 1998