EBP isomerizes ZYMSTNL to LTHSOL

ZYMSTNL → LTHSOL

Reactome

R-HSA-6807052

Compartment

endoplasmic reticulum membrane

Rhea

RHEA:15283

Catalysed by

• steroid Delta-isomerase activity of EBP [endoplasmic reticulum membrane]EC 5.3.3.1; UniProt Q15125

Literature

1. Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome Nat Genet, 1999
2. Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. [email protected]. Nat Genet, 1999
3. Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol J. Biol. Chem., 1960
4. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Elife, 2015