SREBP1A,1C binds the SCD gene
SCD gene + SREBP1A,1C dimer → SREBP1A,1C:SCD gene
- Reactome
- R-HSA-6800052
- Compartment
- nucleoplasm
- Rhea
- None recorded
Inputs
- SCD geneR-HSA-6800051, nucleoplasm
- SREBP1A,1C dimerR-HSA-2065537, nucleoplasm
Outputs
- SREBP1A,1C:SCD geneR-HSA-1655743, nucleoplasm
Catalysed by
- DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C dimer [nucleoplasm]
Literature
- Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes PLoS Genet, 2008
- Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol Biochem Biophys Res Commun, 2001
- Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 J Biol Chem, 1999
- SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest, 2002
- Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes J Biol Chem, 1999