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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AKR1B15 reduces EST17b to E1

EST17b + NADP+ → E1 + NADPH + H+

Reactome: R-HSA-5696822
Compartment: mitochondrial matrix
Rhea: RHEA:24617

Inputs

EST17bCHEBI:16469, C18H24O2, mitochondrial matrix
NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix

Outputs

E1CHEBI:17263, C18H22O2, mitochondrial matrix
NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

estradiol 17-beta-dehydrogenase [NAD(P)+] activity of AKR1B15 [mitochondrial matrix]EC 1.1.1.62; UniProt C9JRZ8

Literature

Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates J. Biol. Chem., 2015