Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2

NR1H4:DCA,CDCA,LCHA + NCOA1,NCOA2,RXRA → NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA

Reactome: R-HSA-5340251
Compartment: nucleoplasm
Rhea: None recorded

Inputs

NR1H4:DCA,CDCA,LCHAR-HSA-5340186, nucleoplasm
NCOA1,NCOA2,RXRAR-HSA-9957259, nucleoplasm

Outputs

NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAR-HSA-5340274, nucleoplasm

Catalysed by

transcription coregulator activity of NCOA1,NCOA2,RXRA [nucleoplasm]

Literature

Bile acids: natural ligands for an orphan nuclear receptor Science, 1999
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis Genes Dev., 2003
Endocrine functions of bile acids EMBO J., 2006
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump Hepatology, 2002
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor J. Biol. Chem., 2001
Identification of a nuclear receptor for bile acids Science, 1999