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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NR1H4 binds DCA, CDCA, LCHA

DCA,CDCA,LCHA + NR1H4 → NR1H4:DCA,CDCA,LCHA

Reactome: R-HSA-5340195
Compartment: nucleoplasm
Rhea: None recorded

Inputs

DCA,CDCA,LCHAR-ALL-5340249, nucleoplasm
NR1H4R-HSA-5340228, nucleoplasm

Outputs

NR1H4:DCA,CDCA,LCHAR-HSA-5340186, nucleoplasm

Catalysed by

bile acid nuclear receptor activity of NR1H4 [nucleoplasm]UniProt Q96RI1

Literature

Bile acids: natural ligands for an orphan nuclear receptor Science, 1999
Identification of a nuclear receptor for bile acids Science, 1999
Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation J. Biol. Chem., 2003
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis Genes Dev., 2003
Endocrine functions of bile acids EMBO J., 2006
FXR, a multipurpose nuclear receptor Trends Biochem. Sci., 2006