Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ARV1 transports CHOL from ER membrane to plasma membrane

CHOL → CHOL

Reactome: R-HSA-5250531
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane · plasma membrane
Rhea: RHEA:39747

Inputs

CHOLCHEBI:16113, C27H46O, endoplasmic reticulum membrane

Outputs

CHOLCHEBI:16113, C27H46O, plasma membrane

Catalysed by

sterol transfer activity of ARV1 [endoplasmic reticulum membrane]UniProt Q9H2C2

Literature

Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1 J. Biol. Chem., 2002
Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1 J. Biol. Chem., 2000