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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PIAS4 SUMOylates VDR with SUMO2

VDR + 2 SUMO2:UBE2I → polySUMO2-VDR + 2 UBE2I

Reactome: R-HSA-4546387
Compartment: nucleoplasm
Rhea: None recorded

Inputs

VDRR-HSA-375512, nucleoplasm
2 SUMO2:UBE2IR-HSA-2993778, nucleoplasm

Outputs

polySUMO2-VDRR-HSA-4546376, nucleoplasm
2 UBE2IR-HSA-912481, nucleoplasm

Catalysed by

SUMO transferase activity of PIAS4 [nucleoplasm]UniProt Q8N2W9

Literature

PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor J. Steroid Biochem. Mol. Biol., 2012