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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PCK2 phosphorylates OA to yield PEP

OA + GTP → PEP + CO2 + GDP

Reactome: R-HSA-372819
Compartment: mitochondrial matrix
Rhea: RHEA:10389

Inputs

OACHEBI:16452, C4H2O5, mitochondrial matrix
GTPCHEBI:37565, C10H12N5O14P3, mitochondrial matrix

Outputs

PEPCHEBI:58702, C3H2O6P, mitochondrial matrix
CO2CHEBI:16526, CO2, mitochondrial matrix
GDPCHEBI:58189, C10H12N5O11P2, mitochondrial matrix

Catalysed by

phosphoenolpyruvate carboxykinase (GTP) activity of PCK2 [mitochondrial matrix]EC 4.1.1.32

PCK2 phosphorylates OA to yield PEP

Inputs

Outputs

Catalysed by

Literature