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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CUBN binds GC:25(OH)D

GC:25(OH)D + CUBN → CUBN:GC:25(OH)D

Reactome: R-HSA-350186
Compartment: extracellular region · plasma membrane
Rhea: None recorded

Inputs

GC:25(OH)DR-HSA-209892, extracellular region
CUBNR-HSA-264843, plasma membrane

Outputs

CUBN:GC:25(OH)DR-HSA-350115, plasma membrane

Catalysed by

cargo receptor activity of CUBN [plasma membrane]

Literature

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3) Proc Natl Acad Sci U S A, 2001