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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

CUBN:GC:25(OH)D → CUBN:GC:25(OH)D

Reactome: R-HSA-350168
Compartment: plasma membrane · extracellular region · cytosol
Rhea: None recorded

Inputs

CUBN:GC:25(OH)DR-HSA-350115, plasma membrane

Outputs

CUBN:GC:25(OH)DR-HSA-350092, cytosol

Catalysed by

cargo receptor activity of LRP2:LDLRAP1 [plasma membrane]

Literature

Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties Eur J Biochem, 1996
Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin J Biol Chem, 1995
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3 Cell, 1999
Role of megalin and cubilin in the metabolism of vitamin D(3) Ther Apher Dial, 2011