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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

G6PC2 hydrolyzes G6P to form Glc and Pi (islet)

G6P + H2O → Pi + Glc

Reactome: R-HSA-3266566
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: RHEA:44905

Inputs

G6PCHEBI:58225, C6H11O9P, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Outputs

PiCHEBI:43474, HO4P, endoplasmic reticulum lumen
GlcCHEBI:4167, C6H12O6, endoplasmic reticulum lumen

Catalysed by

glucose-6-phosphatase activity of G6PC2 [endoplasmic reticulum membrane]EC 3.1.3.9; UniProt Q9NQR9

Literature

Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP) J Biol Chem, 2004