G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)
G6P + H2O → Pi + Glc
- Reactome
- R-HSA-3262512
- Compartment
- endoplasmic reticulum lumen · endoplasmic reticulum membrane
- Rhea
- RHEA:44905
Inputs
- G6PCHEBI:58225, C6H11O9P, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
Outputs
- PiCHEBI:43474, HO4P, endoplasmic reticulum lumen
- GlcCHEBI:4167, C6H12O6, endoplasmic reticulum lumen
Catalysed by
- glucose-6-phosphatase activity of G6PC3 [endoplasmic reticulum membrane]EC 3.1.3.9; UniProt Q9BUM1
Literature
- Identification and characterisation of a new human glucose-6-phosphatase isoform FEBS Lett, 2003
- Histidine 167 is the phosphate acceptor in glucose-6-phosphatase-beta forming a phosphohistidine enzyme intermediate during catalysis J. Biol. Chem., 2004
- A syndrome with congenital neutropenia and mutations in G6PC3 N. Engl. J. Med., 2009