SREBP1A,2 binds the HMGCR promoter
SREBP1A,2 dimer + NF-Y + HMGCR gene → SREBP1A,2:NF-Y:HMGCR gene
- Reactome
- R-HSA-2426162
- Compartment
- nucleoplasm
- Rhea
- None recorded
Inputs
- SREBP1A,2 dimerR-HSA-2065551, nucleoplasm
- NF-YR-HSA-381204, nucleoplasm
- HMGCR geneR-HSA-2393990, nucleoplasm
Outputs
- SREBP1A,2:NF-Y:HMGCR geneR-HSA-2426128, nucleoplasm
Catalysed by
- DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,2,SP1 [nucleoplasm]
Literature
- A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene J Biol Chem, 1996
- Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes PLoS Genet, 2008
- Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Physiol Genomics, 2008
- Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins J Biol Chem, 1998