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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SREBP1A,2 binds the SQLE promoter

SREBP1A,2 dimer + SQLE gene + NF-Y → SREBP1A,2:SQLE gene

Reactome: R-HSA-2426151
Compartment: nucleoplasm
Rhea: None recorded

Inputs

SREBP1A,2 dimerR-HSA-2065551, nucleoplasm
SQLE geneR-HSA-2393973, nucleoplasm
NF-YR-HSA-381204, nucleoplasm

Outputs

SREBP1A,2:SQLE geneR-HSA-2426136, nucleoplasm

Catalysed by

DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,2,NF-Y [nucleoplasm]

Literature

SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase Biochem Biophys Res Commun, 2002
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Physiol Genomics, 2008