SREBP1A,1C,2 binds the HMGCS1 promoter
SREBP1A,1C,2 dimer + NF-Y + HMGCS1 gene → SREBP1A,1C,2:NF-Y:HMGCS1 gene
- Reactome
- R-HSA-2426150
- Compartment
- nucleoplasm
- Rhea
- None recorded
Inputs
- SREBP1A,1C,2 dimerR-HSA-1655744, nucleoplasm
- NF-YR-HSA-381204, nucleoplasm
- HMGCS1 geneR-HSA-2393972, nucleoplasm
Outputs
- SREBP1A,1C,2:NF-Y:HMGCS1 geneR-HSA-2426129, nucleoplasm
Catalysed by
- DNA-binding transcription activator activity, RNA polymerase II-specific of NF-Y,SREBP1A,1C,2 [nucleoplasm]
Literature
- Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase J Biochem, 1998
- Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes PLoS Genet, 2008
- Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes J Lipid Res, 2002
- Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins J Biol Chem, 1998