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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SREBP1A,1C binds the FASN promoter

SREBP1A,1C dimer + NF-Y + SP1 + FASN gene → SREBP1A,1C:NF-Y:SP1:FASN gene

Reactome: R-HSA-2426148
Compartment: nucleoplasm
Rhea: None recorded

Inputs

SREBP1A,1C dimerR-HSA-2065537, nucleoplasm
NF-YR-HSA-381204, nucleoplasm
SP1R-HSA-1592223, nucleoplasm
FASN geneR-HSA-2393979, nucleoplasm

Outputs

SREBP1A,1C:NF-Y:SP1:FASN geneR-HSA-1655738, nucleoplasm

Catalysed by

DNA-binding transcription activator activity, RNA polymerase II-specific of SREBP1A,1C,NF-Y,SP1 [nucleoplasm]

Literature

Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways J Biol Chem, 1995
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN) J Biol Chem, 2008
Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites Proc Natl Acad Sci U S A, 2000
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Physiol Genomics, 2008
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes J Lipid Res, 2002
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins J Biol Chem, 1998