SREBP1A,1C,2 binds the FDPS promoter
SREBP1A,1C,2 dimer + NF-Y + FDPS gene → SREBP1A,1C,2:NF-Y:FDPS gene
- Reactome
- R-HSA-2426147
- Compartment
- nucleoplasm
- Rhea
- None recorded
Inputs
- SREBP1A,1C,2 dimerR-HSA-1655744, nucleoplasm
- NF-YR-HSA-381204, nucleoplasm
- FDPS geneR-HSA-2393989, nucleoplasm
Outputs
- SREBP1A,1C,2:NF-Y:FDPS geneR-HSA-2426134, nucleoplasm
Catalysed by
- DNA-binding transcription activator activity, RNA polymerase II-specific of NF-Y,SREBP1A,1C,2 [nucleoplasm]
Literature
- Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells Biochem J, 2010
- Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene J Biol Chem, 1996
- Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes PLoS Genet, 2008
- Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Physiol Genomics, 2008
- Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes J Lipid Res, 2002
- Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins J Biol Chem, 1998