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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum

4 INSIG:oxysterol + SREBP1A,1C,2:SCAP → SREBP1A,1C,2:SCAP:INSIG:oxysterol

Reactome: R-HSA-2317531
Compartment: endoplasmic reticulum membrane
Rhea: None recorded

Inputs

4 INSIG:oxysterolR-HSA-2317517, endoplasmic reticulum membrane
SREBP1A,1C,2:SCAPR-HSA-2317520, endoplasmic reticulum membrane

Outputs

SREBP1A,1C,2:SCAP:INSIG:oxysterolR-HSA-2317522, endoplasmic reticulum membrane

Catalysed by

protein sequestering activity of SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane]