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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum

SREBP1A,1C,2:SCAP + 4 INSIG + 4 CHOL → SREBP1A,1C,2:SCAP:cholesterol:INSIG

Reactome: R-HSA-2317530
Compartment: endoplasmic reticulum membrane
Rhea: None recorded

Inputs

SREBP1A,1C,2:SCAPR-HSA-2317520, endoplasmic reticulum membrane
4 INSIGR-HSA-1655749, endoplasmic reticulum membrane
4 CHOLCHEBI:16113, C27H46O, endoplasmic reticulum membrane

Outputs

SREBP1A,1C,2:SCAP:cholesterol:INSIGR-HSA-1655766, endoplasmic reticulum membrane

Catalysed by

protein sequestering activity of SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane]