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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IL4I1:FAD oxidises L-Phe to kPPV

L-Phe + H2O + O2 → kPPV + H2O2 + NH4+

Reactome: R-HSA-2160492
Compartment: extracellular region
Rhea: RHEA:61241

Inputs

L-PheCHEBI:58095, C9H11NO2, extracellular region
H2OCHEBI:15377, H2O, extracellular region
O2CHEBI:15379, O2, extracellular region

Outputs

kPPVCHEBI:18005, C9H7O3, extracellular region
H2O2CHEBI:16240, H2O2, extracellular region
NH4+CHEBI:28938, H4N, extracellular region

Catalysed by

L-amino-acid oxidase activity of IL4I1:FAD [extracellular region]EC 1.4.3.2

Literature

Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation Blood, 2007