CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
1,25(OH)2D + NADPH + H+ + O2 → CTA + NADP+ + H2O
- Reactome
- R-HSA-209765
- Compartment
- mitochondrial inner membrane · cytosol
- Rhea
- None recorded
Inputs
- 1,25(OH)2DCHEBI:17823, C27H44O3, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
- O2CHEBI:15379, O2, cytosol
Outputs
- CTACHEBI:47828, C23H34O4, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
Catalysed by
- 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]UniProt Q07973
Literature
- Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA Proc Natl Acad Sci U S A, 1993
- Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme Biochemistry, 1996
- Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24 Eur J Biochem, 2000