SREBP1A,1C,2 binds the TM7SF2 promoter
NF-Y + TM7SF2 gene + SREBP1A,1C,2 dimer → SREBP1A,1C,2:NF-Y:TM7SF2 gene
- Reactome
- R-HSA-2065966
- Compartment
- nucleoplasm
- Rhea
- None recorded
Inputs
- NF-YR-HSA-381204, nucleoplasm
- TM7SF2 geneR-HSA-2393984, nucleoplasm
- SREBP1A,1C,2 dimerR-HSA-1655744, nucleoplasm
Outputs
- SREBP1A,1C,2:NF-Y:TM7SF2 geneR-HSA-1655714, nucleoplasm
Catalysed by
- DNA-binding transcription activator activity, RNA polymerase II-specific of NF-Y,SREBP1A,1C,2 [nucleoplasm]
Literature
- Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box Biochim Biophys Acta, 2010
- Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes PLoS Genet, 2008
- Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle Physiol Genomics, 2008