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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SREBP1A,1C,2:Importin beta-1 dissociates

SREBP1A,1C,2:Importin beta-1 + RAN:GTP → SREBP1A,1C,2 dimer + Importin-beta:Ran GTP complex

Reactome: R-HSA-2065539
Compartment: nucleoplasm
Rhea: None recorded

Inputs

SREBP1A,1C,2:Importin beta-1R-HSA-2065543, nucleoplasm
RAN:GTPR-HSA-180738, nucleoplasm

Outputs

SREBP1A,1C,2 dimerR-HSA-1655744, nucleoplasm
Importin-beta:Ran GTP complexR-HSA-180719, nucleoplasm

Catalysed by

importin-alpha family protein binding activity of RAN:GTP [nucleoplasm]

Literature

Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip Mol Biol Cell, 1999