SLC7A4 exchanges G6P for Pi across the ER membrane
G6P + Pi → G6P + Pi
- Reactome
- R-HSA-198513
- Compartment
- cytosol · endoplasmic reticulum membrane · endoplasmic reticulum lumen
- Rhea
- RHEA:71537
Inputs
- G6PCHEBI:58225, C6H11O9P, cytosol
- PiCHEBI:43474, HO4P, endoplasmic reticulum lumen
Outputs
- G6PCHEBI:58225, C6H11O9P, endoplasmic reticulum lumen
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- glucose 6-phosphate:phosphate antiporter activity of SLC37A4 [endoplasmic reticulum membrane]UniProt O43826
Literature
- The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic FASEB J., 2008
- Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib FEBS Lett, 1997
- A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic Am. J. Hum. Genet., 1998