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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Reduction of desmosterol to cholesterol

DESMOL + NADPH + H+ → CHOL + NADP+

Reactome: R-HSA-196417
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:36391, RHEA:36393

Inputs

DESMOLCHEBI:17737, C27H44O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

CHOLCHEBI:16113, C27H46O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

Delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]EC 1.3.1.72; UniProt Q15392

Literature

Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis Am J Hum Genet, 2001